An Ingestible Light Source for Deep Photoacoustic Imaging

TL;DR

This paper introduces a novel ingestible device that uses wireless acoustic energy to power an internal light source, enabling deep tissue photoacoustic imaging beyond traditional optical limits.

Contribution

The study presents a compact, acoustically powered light source for deep photoacoustic imaging, overcoming optical attenuation constraints of conventional systems.

Findings

Successfully imaged through 12 cm phantom tissue

Demonstrated wireless powering of internal light source

Enabled deep tissue photoacoustic imaging beyond optical limits

Abstract

Photoacoustic tomography leverages ultrasound's deep tissue penetration to retrieve optical absorption contrast well beyond the optical diffusion limit. Conventional photoacoustic systems rely on externally delivered light and are therefore constrained by optical attenuation, limiting imaging depths to several centimeters. Here, we overcome this constraint using a compact, acoustically powered device that provides optical excitation directly from within the target medium. By exploiting the weak attenuation of low-MHz ultrasound, acoustic energy is transmitted through tissue to wirelessly power a pulsed laser diode. The emitted light pulses generate photoacoustic signals that encode local optical absorption at clinically relevant depths, which could enable imaging in regions such as the gastrointestinal tract that are inaccessible to surface-based illumination. We demonstrate this approach by imaging through a 12 cm thick phantom, establishing a pathway toward deep-tissue photoacoustic imaging.