Zero-Dimensional Cardiovascular Modeling: A Personalized Approach to Non-Invasive Measurement and Sensitivity Analysis

TL;DR

This study compares simple and detailed zero-dimensional cardiovascular models to understand how model complexity affects parameter sensitivity, aiding in model reduction and non-invasive cardiovascular analysis.

Contribution

It provides a systematic sensitivity analysis of two different cardiovascular models, revealing how model structure influences parameter importance and interactions.

Findings

Sensitivity rankings differ significantly between models

Model granularity affects parameter influence

Results support sensitivity-based model simplification

Abstract

Zero-dimensional cardiovascular models provide a computationally efficient framework for studying global hemodynamic behavior, yet the influence of model complexity on parameter sensitivity remains insufficiently understood. This work investigates two lumped-parameter cardiovascular models, a simplified single-ventricle configuration and a detailed four-chamber representation, to examine how physiological parameter sensitivities vary with model structure. Time-varying elastance functions are used to represent cardiac dynamics, and global sensitivity analysis is performed using Sobol and Morris methods to quantify the impact of key physiological parameters, including venous return, myocardial contractility, total peripheral resistance, and arterial compliance. The results demonstrate that sensitivity rankings differ substantially between the two models, highlighting the role of model granularity and parameter interactions in shaping cardiovascular responses. These findings support sensitivity-driven model reduction and provide a foundation for scalable, non-invasive cardiovascular simulation frameworks.