Quantifying the Lifelong Impact of Resilience Interventions via Agent-Based LLM Simulation
Vivienne L'Ecuyer Ming (Possibility Sciences, The Human Trust, Neurotech Collider Lab at UC Berkeley)

TL;DR
This paper introduces LALS, a simulation framework using large language models to estimate the long-term causal effects of resilience interventions on life outcomes, revealing critical developmental windows and socioeconomic disparities.
Contribution
The paper presents a novel agent-based simulation method that enables precise long-term causal inference of psychological interventions using LLM-generated digital clones.
Findings
Intervention at age 6 more than doubles wealth impact compared to age 18.
Resilience training reduces mortality and dementia incidence.
Low-socioeconomic agents benefit most from early interventions.
Abstract
Establishing the long-term, causal impact of psychological interventions on life outcomes is a grand challenge for the social sciences, caught between the limitations of correlational longitudinal studies and short-term randomized controlled trials (RCTs). This paper introduces Large-Scale Agent-based Longitudinal Simulation (LALS), a framework that resolves this impasse by simulating multi-decade, counterfactual life trajectories. The methodology employs a "digital clone" design where 2,500 unique LLM-based agent personas (grounded in a curated corpus of 3,917 empirical research articles) are each cloned across a 2x2 factorial experiment. Specifically, the simulation models the efficacy of extended psychological resilience training (Intervention vs. Control) either in childhood or as a young adult (age 6 vs. age 18). Comparing digital clones enables exceptionally precise causal…
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Taxonomy
TopicsPersona Design and Applications · Mental Health Research Topics · Health, Environment, Cognitive Aging
