Coord2Region: A Python Package for Mapping 3D Brain Coordinates to Atlas Labels, Literature, and AI Summaries
Hamza Abdelhedi, Yorguin-Jose Mantilla-Ramos, Sina Esmaeili, Annalisa Pascarella, Vanessa Hadid, Karim Jerbi

TL;DR
Coord2Region is a Python package that automates mapping 3D brain coordinates to anatomical regions, links them to neuroimaging literature, and generates AI-based summaries to enhance neuroimaging research workflows.
Contribution
It introduces a comprehensive, open-source tool integrating coordinate mapping, literature linking, and AI summaries, streamlining neuroimaging analysis and interpretation workflows.
Findings
Supports batch and single-coordinate queries
Integrates with NiMARE, Neurosynth, NeuroQuery
Provides web interface and cloud execution
Abstract
We present Coord2Region, an open-source Python package that streamlines coordinate-based neuroimaging workflows by automatically mapping 3D brain coordinates (e.g., MNI or Talairach) to anatomical regions across multiple atlases. The package links mapped coordinates to meta-analytic resources via the Neuroimaging Meta-Analysis Research Environment (NiMARE) , providing direct integration with Neurosynth and NeuroQuery. This directly connects coordinates and regions to the broader neuroimaging literature. In addition to atlas-based labeling and literature retrieval, Coord2Region offers an optional large language model (LLM) functionality that generates text summaries of linked studies and illustrative images of queried regions. These AI-assisted features are intended to support interpretation and exploration, while remaining clearly complementary to peer-reviewed literature and…
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Taxonomy
TopicsFunctional Brain Connectivity Studies · Cell Image Analysis Techniques · Neural dynamics and brain function
