HiLTS: Human in the Loop Therapeutic System: A Wireless-enabled Precision Medicine Platform for Brainwave Entrainment
Arfan Ghani

TL;DR
This paper presents a minimal digital chip capable of generating a 6 Hz rhythm to entrain epileptic seizures, demonstrating a low-power, simplified approach for potential wearable seizure intervention devices.
Contribution
Introduces a custom-designed digital chip for neural entrainment at 6 Hz, offering a low-power, simplified alternative to complex existing neuromodulation systems.
Findings
The chip produces a stable 6 Hz oscillation that overrides seizure activity.
Frequency and time domain analyses confirm effective seizure entrainment.
Proof-of-concept for low-power, wearable seizure intervention devices.
Abstract
Epileptic seizures arise from abnormally synchronised neural activity and remain a major global health challenge, affecting more than 50 million people worldwide. Despite advances in pharmacological interventions, a significant proportion of patients continue to experience uncontrolled seizures, underscoring the need for alternative neuromodulation strategies. Rhythmic neural entrainment has recently emerged as a promising mechanism for disrupting pathological synchrony, but most existing systems rely on complex analogue electronics or high-power stimulation hardware. This study investigates a minimal digital custom-designed chip that generates a stable 6 Hz oscillation capable of entraining epileptic seizure activity. Using a publicly available EEG seizure dataset, we extracted and averaged analogue seizure waveforms, digitised them to emulate neural front-ends, and directly interfaced…
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Taxonomy
TopicsEEG and Brain-Computer Interfaces · Neurological disorders and treatments · Muscle activation and electromyography studies
