Macular: a multi-scale simulation platform for the retina and the primary visual system
Bruno Cessac, Erwan Demairy, J\'er\^ome Emonet, Evgenia Kartsaki, Thibaud Kloczko, C\^ome Le Breton, Nicolas Niclausse, Selma Souihel, Jean-Luc Szpyrka, Julien Wintz

TL;DR
Macular is a versatile simulation platform with a graphical interface for modeling the retina and visual cortex, enabling in silico experiments with customizable structures, inputs, and parameters for neurobiologists and modelers.
Contribution
It introduces a user-friendly, graphical simulation environment for the retina and visual system, allowing hypothesis testing without programming expertise.
Findings
Supports complex multi-layer 3D structures
Enables simulation of various physiological and pathological conditions
Provides customizable cell and synapse models
Abstract
We developed Macular, a simulation platform with a graphical interface, designed to produce in silico experiment scenarios for the retina and the primary visual system. A scenario consists of generating a three-dimensional structure with interconnected layers, each layer corresponding to a type of 'cell' in the retina or visual cortex. The cells can correspond to neurons or more complex structures (such as cortical columns). The inputs are arbitrary videos. The user can use the cells and synapses provided with the software, or create their own using a graphical interface where they enter the constituent equations in text format (e.g., LaTeX). They also create the three-dimensional structure via the graphical interface. Macular then automatically generates and compiles the C++ code and generates the simulation interface. This allows the user to view the input video and the…
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Taxonomy
TopicsRetinal Imaging and Analysis
