Robust Detection of Retinal Neovascularization in Widefield Optical Coherence Tomography

TL;DR

This paper introduces a deep learning method for detecting and staging retinal neovascularization in widefield OCTA images, achieving high accuracy and enabling longitudinal monitoring.

Contribution

The study presents a novel direct binary localization approach for RNV detection in widefield OCTA, outperforming traditional segmentation-dependent methods.

Findings

Achieved AUC of 0.96 to 0.99 for RNV diagnosis

Achieved IOU of 0.76 to 0.88 for segmentation

Demonstrated longitudinal monitoring of lesion growth

Abstract

Retinal neovascularization (RNV) is a vision threatening development in diabetic retinopathy (DR). Vision loss associated with RNV is preventable with timely intervention, making RNV clinical screening and monitoring a priority. Optical coherence tomography (OCT) angiography (OCTA) provides high-resolution imaging and high-sensitivity detection of RNV lesions. With recent commercial devices introducing widefield OCTA imaging to the clinic, the technology stands to improve early detection of RNV pathology. However, to meet clinical requirements these imaging capabilities must be combined with effective RNV detection and quantification, but existing algorithms for OCTA images are optimized for conventional, i.e. narrow, fields of view. Here, we present a novel approach for RNV diagnosis and staging on widefield OCT/OCTA. Unlike conventional methods dependent on multi-layer retinal segmentation, our model reframes RNV identification as a direct binary localization task. Our fully automated approach was trained and validated on 589 widefield scans (17x17-mm to 26x21-mm) collected from multiple devices at multiple clinics. Our method achieved a device-dependent area under curve (AUC) ranging from 0.96 to 0.99 for RNV diagnosis, and mean intersection over union (IOU) ranging from 0.76 to 0.88 for segmentation. We also demonstrate our method's ability to monitor lesion growth longitudinally. Our results indicate that deep learning-based analysis for widefield OCTA images could offer a valuable means for improving RNV screening and management.