Survival and invasion dynamics in cell populations: an analytical framework for threshold behaviour in nonlinear age-structured models

TL;DR

This paper develops an analytical framework for age-structured cell populations, revealing how age-dependent division rates influence invasion speed, steady states, and survival conditions, contrasting with classical models.

Contribution

It introduces a moment-hierarchy model incorporating age-dependent division rates, providing explicit formulas and fundamental principles for invasion dynamics.

Findings

Age structure reduces carrying capacity.

Invasion speeds are slower with age-dependent division.

Survival condition matches invasion speed positivity.

Abstract

Cell populations invade through a combination of proliferation and motility. Proliferation depends on the internal timing of cell division: how long cells take to complete the cell cycle. This timing varies substantially within (and across) cell types, creating age structure where cells at different times since their last division have different propensities to divide. Classical mathematical models of cell spreading treat division as memoryless and predict exponential cell-cycle-time distributions. Lineage tracing, by contrast, reveals peaked, gamma-like distributions that indicate a maturation delay leading to a fertility window. This gap motivates a modelling framework that incorporates age-dependent cell division rates while retaining analytical tractability. We address this through a moment-hierarchy framework that tracks time since cell division, with age resetting to zero at division. The framework yields explicit formulae for steady-state age distributions, cell-cycle-time distributions, and invasion speeds. For age-independent rates, we recover classical Fisher--KPP. Three fundamental principles emerge. First, age structure systematically reduces a population's carrying capacity and narrows the viable parameter range for positive steady states. Second, classical linear theory overestimates invasion speeds; the true minimal speed is slower when division is age-dependent. Third, the parameter condition for population survival is identical to the condition for a positive invasion speed.