From Cantilevers to Membranes: Advanced Scanning Protocols for Magnetic Resonance Force Microscopy

TL;DR

This paper presents advanced scanning protocols and optimized resonators for Magnetic Resonance Force Microscopy, significantly reducing acquisition time and enhancing imaging of biological nanostructures.

Contribution

Introduction of a multislice, compressed-sensing scan protocol combined with strained SiN resonators to improve MRFM efficiency and resolution.

Findings

Simulation predicts up to 100x reduction in measurement time

Out-of-plane oscillation improves sample reconstruction quality

Protocols enable high-resolution volumetric imaging of biological nanostructures

Abstract

Magnetic Resonance Force Microscopy (MRFM) enables three-dimensional imaging of nuclear spin densities in nanoscale objects. Based on numerical simulations, we evaluate the performance of strained SiN resonators as force sensors and show that their out-of-plane oscillation direction improves the quality of the reconstructed sample. We further introduce a multislice, compressed-sensing scan protocol that maximizes the information obtained for a given measurement time. Our simulations predict that these new scanning protocols and optimized algorithms can shorten the total acquisition time by up to two orders of magnitude while maintaining the reconstruction fidelity. Our results demonstrate that combining advanced scanning protocols with state-of-the-art resonators is a promising path toward high-resolution MRFM for volumetric imaging of biological nanostructures.