Ultrasensitive surface plasmon resonance-based biosensor for efficient detection of SARS-CoV-2 Virus in the near-infrared region

TL;DR

This paper introduces a multilayered surface plasmon resonance biosensor operating in the near-infrared region, achieving high sensitivity and detection accuracy for SARS-CoV-2, through numerical simulation of its layered structure.

Contribution

The work presents a novel multilayered SPR sensor design with optimized layers and materials, enhancing detection performance for viral biosensing applications.

Findings

Maximum sensitivity of 372°/RIU

FOM of 1690.90 RIU-1

Detection accuracy of 4.54°^{-1}

Abstract

This work presents a high-performance, multilayered surface plasmon resonance (SPR)-based sensor designed to enhance performance parameters in the near-infrared (NIR) region through angular interrogation. The multi-layered sensor consists of a bimetallic layer (Aluminum (Al) & Gold (Au)), a dielectric layer (MgF2), and an optimized number of 2D nanomaterial (MoS2) layers. The proposed SPR sensor is numerically designed and analyzed through simulation using the transfer matrix and finite element methods to achieve high sensitivity, figure of merit (FOM), and detection accuracy. The simulated results revealed that the proposed plasmonic sensor (Glass prism/Al/Au/MgF2/MoS2/sensing sample) exhibits a maximum sensitivity of 372{\deg}/RIU, FOM of 1690.90 RIU-1, and detection accuracy of 4.54 degree-1. The outcomes from this work indicate that the developed SPR sensor exhibits excellent detection capabilities for refractive index changes, including those caused by the novel coronavirus, making it a promising prospect for biosensing applications.