Variational Percolation Bounds for Cellular Membrane Occlusion

TL;DR

This paper develops a theoretical framework linking membrane chemistry and geometry to transport suppression, providing bounds and spectral analysis to predict cellular membrane behavior and redox states.

Contribution

It introduces a novel mathematical model combining electrodiffusion, interfacial potential, and energetic modules to predict membrane transport and redox collapse.

Findings

Capacitary-spectral bounds relate flux to eigenvalues.

Geometry and field strength control transport suppression.

Model predicts membrane behavior and redox thresholds.

Abstract

Malignant membranes cluster nutrient transporters within glycan-rich domains, sustaining metabolism through redundant intake routes. A theoretical framework links interfacial chemistry to transport suppression and energetic or redox collapse. The model unites a screened Poisson-Nernst-Planck electrodiffusion problem, an interfacial potential of mean force, and a reduced energetic-redox module connecting flux to ATP/NADPH balance. From this structure, capacitary-spectral bounds relate total flux to the inverse principal eigenvalue (J_tot <= C*exp(-beta*chi_eff)*P(theta)). Two near-orthogonal levers, geometry and field strength, govern a linear suppression regime below a percolation-type knee, beyond which conductance collapses. A composite intake index Xi = w_G*J_GLUT + w_A*J_LAT/ASCT + w_L*J_MCT dictates energetic trajectories: once below a maintenance threshold, ATP and NADPH fall jointly and redox imbalance drives irreversible commitment. Normal membranes, with fewer transport mouths and weaker fields, remain above this threshold, defining a natural selectivity window. The framework demonstrates existence, regularity, and spectral monotonicity for the self-adjoint PNP operator, establishing a geometric-spectral transition that links molecular parameters such as branching and sulfonation to measurable macroscopic outcomes with predictive precision.