# Quantitative imaging of 478-keV prompt gamma rays from boron neutron capture reactions

## TL;DR

This paper presents a specialized gamma-ray imaging detector for precise measurement of 478-keV prompt gamma rays in BNCT, enabling accurate boron dose monitoring during cancer treatment.

## Contribution

The study introduces a novel gamma-ray detector tailored for BNCT, demonstrating successful imaging and dose monitoring in phantom and clinical settings.

## Key findings

- Successful imaging of 478-keV gamma rays from boron reactions
- Established linear correlation between gamma-ray counts and boron concentration
- Effective in vivo boron dose monitoring during BNCT treatments

## Abstract

The accurate imaging and quantitative measurement of 478-keV prompt gamma rays are critical for advancing boron neutron capture therapy (BNCT), a promising cancer treatment. Although numerical simulations have indicated that such measurements are feasible, their practical application has proven challenging. This study introduces a gamma-ray imaging detector designed specifically for precise BNCT measurements. Using boron-rich phantom samples, we successfully imaged 478-keV gamma rays and established a linear correlation between gamma-ray production and boron concentration. Furthermore, applying this technique in a recognized BNCT treatment facility demonstrated the detector's effectiveness in monitoring boron dose distribution during neutron irradiation, both in pretreatment diagnostics and throughout the treatment process.

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Source: https://tomesphere.com/paper/2509.00435