Deep Learning-Assisted Detection of Sarcopenia in Cross-Sectional Computed Tomography Imaging

TL;DR

This study develops deep learning models to automate the measurement of skeletal muscle area in CT images for sarcopenia detection, achieving high accuracy and enabling scalable, efficient diagnosis.

Contribution

It introduces transfer learning and self-supervised learning techniques for automated SMA measurement, improving efficiency and addressing data limitations.

Findings

Average prediction error of +-3 percentage points

Dice similarity coefficient of 93% for segmentation masks

Pathway to fully automated sarcopenia detection

Abstract

Sarcopenia is a progressive loss of muscle mass and function linked to poor surgical outcomes such as prolonged hospital stays, impaired mobility, and increased mortality. Although it can be assessed through cross-sectional imaging by measuring skeletal muscle area (SMA), the process is time-consuming and adds to clinical workloads, limiting timely detection and management; however, this process could become more efficient and scalable with the assistance of artificial intelligence applications. This paper presents high-quality three-dimensional cross-sectional computed tomography (CT) images of patients with sarcopenia collected at the Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust. Expert clinicians manually annotated the SMA at the third lumbar vertebra, generating precise segmentation masks. We develop deep-learning models to measure SMA in CT images and automate this task. Our methodology employed transfer learning and self-supervised learning approaches using labelled and unlabeled CT scan datasets. While we developed qualitative assessment models for detecting sarcopenia, we observed that the quantitative assessment of SMA is more precise and informative. This approach also mitigates the issue of class imbalance and limited data availability. Our model predicted the SMA, on average, with an error of +-3 percentage points against the manually measured SMA. The average dice similarity coefficient of the predicted masks was 93%. Our results, therefore, show a pathway to full automation of sarcopenia assessment and detection.