Self-propulsion via non-transitive phase coexistence in chemically active mixtures

TL;DR

This paper explores how active reactions in chemically active mixtures influence phase separation, leading to non-transitive coexistence and self-propelled phases, revealing complex dynamics beyond equilibrium physics.

Contribution

It introduces the concept that active reactions cause non-transitive phase coexistence and self-propulsion, expanding understanding of phase behavior in active biological systems.

Findings

Active reactions alter chemical potential balance.

Phase coexistence becomes non-transitive.

Self-propelled phases emerge in active mixtures.

Abstract

Phase separation drives the formation of biomolecular condensates in cells, which comprise many components and sometimes possess multiple phases. The equilibrium physics of phase separation is well understood, but many components in condensates undergo active reactions. We demonstrate that such reactions affect phase separation by altering the chemical potential balance and by introducing an osmotic pressure difference at interfaces. However, the system does not permit a pseudo-pressure balance, and bulk compositions depend on which phases are in contact. Moreover, phase coexistence is no longer transitive, which enables self-propelled phases and more complex dynamics.