An Interactive Platform for Unified Assessment of Drug-Drug Interactions Using Descriptive and Pharmacokinetic Data

TL;DR

This paper introduces an interactive web platform that integrates descriptive and pharmacokinetic drug-drug interaction data, facilitating research and education in pharmacology with real-time, user-friendly exploration tools.

Contribution

The novel platform combines large-scale DDI data with pharmacokinetic information using NLP and manual curation, offering a unified, interactive tool for comprehensive drug interaction assessment.

Findings

Integrated 191,541 descriptive DDI records with 3,779 pharmacokinetic interactions.

Unified 1,803 interaction pairs across 639 compounds through multi-step harmonization.

Built a user-friendly Streamlit app for real-time exploration of drug interactions.

Abstract

Drug-drug interactions (DDIs) are a major concern in polypharmacy. Public databases often provide only qualitative descriptions without pharmacokinetic context. We present an interactive web tool that integrates 191,541 descriptive DDI records from DrugBank with 3,779 AUC-based interactions from the PK-DDIP dataset, extracted from FDA-approved drug labeling (DailyMed) using natural language processing and manual verification. Using multi-step name harmonization (exact, fuzzy, synonym expansion, manual curation), 1,803 interaction pairs were unified across 639 overlapping compounds. The platform is built with Streamlit and offers smart drug search, color-coded output, and real-time response. It enables users to explore both descriptive and pharmacokinetic data, supporting research and education in clinical pharmacology and drug safety. This research prototype is not intended for clinical decision-making.