Precision Profile Weighted Deming Regression for Methods Comparison
Douglas M Hawkins, Jessica J Kraker

TL;DR
This paper introduces a methodology that combines precision profile models with Deming regression to improve methods comparison involving measurements with nonconstant variance, supported by R routines.
Contribution
It presents a novel approach integrating precision profile models with Deming regression, along with R routines for practical implementation.
Findings
Effective weighting for nonconstant variance in Deming regression
Enhanced accuracy in methods comparison across measurement ranges
Provision of R routines for practical application
Abstract
Errors in variables (Deming) regression of measurements spanning a wide range of values requires appropriate weighting to reflect nonconstant variance. Precision profile models, mathematical relationships between measurement variance and mean, are a route to these weights. The paper describes a methodology combining general precision profile models with Deming regression and described R routines for the resulting calculations.
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