Comprehensive characterization of nonlinear viscoelastic properties of arterial tissues using guided-wave optical coherence elastography

TL;DR

This study introduces a broadband guided-wave optical coherence elastography technique to comprehensively characterize the nonlinear viscoelastic, anisotropic, and layer-specific properties of arterial tissues, revealing their complex mechanical behavior.

Contribution

The paper presents a novel OCE method based on viscoelasto-acoustic theory for detailed, high-resolution profiling of arterial tissue biomechanics, including nonlinear and layer-specific properties.

Findings

Viscoelasticity of arteries depends strongly on stretch and prestress.

Adventitia becomes stiffer than media under mechanical load due to collagen engagement.

Collagen degradation affects nonlinear viscoelastic behavior.

Abstract

The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography, comprehensive characterization of the complex mechanical behavior of arterial tissues remains challenging. Here, we present a broadband guided-wave optical coherence elastography (OCE) technique, grounded in viscoelasto-acoustic theory, for quantifying the nonlinear viscoelastic, anisotropic, and layer-specific properties of arterial walls with high spatial and temporal resolution. Our results reveal a strong stretch dependence of arterial viscoelasticity, with increasing prestress leading to a reduction in tissue viscosity. Under mechanical loading, the adventitia becomes significantly stiffer than the media, attributable to engagement of collagen fibers. Chemical degradation of collagen fibers highlighted their role in nonlinear viscoelasticity. This study demonstrates the potential of OCE as a powerful tool for detailed profiling of vascular biomechanics, with applications in basic research and future clinical diagnosis.