Enhanced molecular diffusion near a soft fluctuating membrane

TL;DR

This study numerically investigates how solvent molecules diffuse near a thermally fluctuating lipid membrane, revealing enhanced diffusion due to momentum exchanges that promote mixing, differing from behavior near rigid interfaces.

Contribution

It provides new insights into molecular-scale diffusion dynamics near soft, fluctuating biological membranes, highlighting mechanisms distinct from those near hard interfaces.

Findings

Diffusive motion of solvent molecules is slightly enhanced near fluctuating membranes.

Momentum exchanges promote mixing and overcome geometric trapping.

Effective slip boundary condition emerges from membrane fluctuations.

Abstract

Particles diffusing near interfaces face anisotropic resistance to motion due to hydrodynamic interactions. While this has been extensively studied near \textit{hard} interfaces since the works of Lorentz and Brenner, our understanding of diffusion near \textit{soft, thermally fluctuating} interfaces remains limited. Previous studies have predominantly focused on particles much larger than the molecular scale at which thermal fluctuations become important. In this work, we numerically investigate the dynamics of individual solvent molecules near a thermally fluctuating lipid membrane, a canonical soft interface in biology. We observe that diffusive motion of solvent molecules near the fluctuating membrane is slightly enhanced compared to a flat rigid interface and significantly more so than near an undulated rigid interface. This enhancement in diffusive motion of solvent molecules arises from spontaneous momentum exchanges between the moving membrane and adjacent molecules, promoting mixing. Notably, this dispersion effect overcomes geometric trapping that slows diffusion near the rigid undulated interface. Our analysis reveals that the momentum transfer near the fluctuating membrane is so efficient that it resembles an effective slip boundary condition over a length scale equal to the fluctuation height. These molecular-scale mechanisms differ from those of larger particles, where hydrodynamic memory and elasticity effects can be at play as they relax over timescales comparable to significant diffusive motion. Our findings advance understanding of enhanced diffusive motion and promoted mixing near soft fluctuating membranes involved in diverse biological processes and soft-matter technologies containing natural and model cell membranes.