A general multi-stratum model for a nanofunctionalized releasing capsule: a computational study

TL;DR

This paper develops a computational multi-stratum model for nanofunctionalized releasing capsules, enabling detailed analysis of drug release kinetics and aiding the design of advanced drug delivery systems.

Contribution

It extends existing models to include multi-layered capsule structures and provides a numerical framework for predicting release profiles with experimental validation.

Findings

Good agreement with in vitro data

Parameter sensitivity analysis reveals key factors affecting release

Analytical expressions enable rapid evaluation of design options

Abstract

Releasing capsules are widely employed in biomedical applications as smart carriers of therapeutic agents, including drugs and bioactive compounds. Such delivery vehicles typically consist of a loaded core, enclosed by one or multiple concentric coating strata. In this work, we extend over existing mechanistic models to account for such multi-strata structures, and we characterise the release kinetics of the active substance into the surrounding medium. We present a computational study of drug release from a multi-stratum spherical microcapsule, modelled through a non-linear diffusion equation incorporating radial anisotropy and space- and time-discontinuous coefficients. The problem is solved numerically using a finite volume scheme on a grid with adaptive spatial and temporal resolution. Analytical expressions for concentration and cumulative release are derived for all strata, enabling the exploration of parameter sensitivity -- such as coating permeability and internal diffusivity -- on the overall release profile. The resulting release curves provide mechanistic insight into the transport processes and offer design criteria for achieving controlled release. Model predictions are benchmarked against in vitro experimental data obtained under physiologically relevant conditions, showing good agreement and validating the key features of the model. The proposed model thus serves as a practical tool for predicting the behaviour of composite coated particles, supporting performance evaluation and the rational design of next-generation drug delivery systems with reduced experimental effort.