A Prior-Guided Joint Diffusion Model in Projection Domain for PET Tracer Conversion

TL;DR

This paper introduces a prior-guided joint diffusion model that transforms PET sinograms from one tracer to another, improving quality and accuracy for medical diagnosis, especially for neuroendocrine tumors.

Contribution

The study presents a novel diffusion model that leverages prior information to convert PET sinograms between tracers, enhancing clinical applicability and image quality.

Findings

Significant improvement in sinogram quality

Enhanced accuracy of synthetic PET images

Effective in clinical scenarios for neuroendocrine tumors

Abstract

Positron emission tomography (PET) is widely used to assess metabolic activity, but its application is limited by the availability of radiotracers. 18F-labeled fluorodeoxyglucose (18F-FDG) is the most commonly used tracer but shows limited effectiveness for certain tumors. In contrast, 6-18F-fluoro-3,4-dihydroxy-L-phenylalanine (18F-DOPA) offers higher specificity for neuroendocrine tumors and neurological disorders. However, the complexity of its synthesis process and constraints on transportation time have limited its clinical application. Among different forms of raw data acquired by the scanner, sinogram is a commonly used representation in PET imaging. Therefore, modeling in projection domain enables more direct utilization of the original information, potentially reducing the accumulation errors during the image reconstruction process. Inspired by these factors, this study proposes a prior-guided joint diffusion model (PJDM) for transforming 18F-FDG PET sinograms into 18F-DOPA PET sinograms. During inference, an initial synthetic 18F-DOPA PET sinogram is first generated using a higher-order hybrid sampler. This sinogram is then degraded and serves as an additional condition to guide the iterative refinement process. Experimental results demonstrated that PJDM effectively improved both sinogram quality and the final synthetic outcomes. The code is available at: https://github.com/yqx7150/PJDM.