Translational dynamics of lipid-coated microbubbles driven by ultrasound

TL;DR

This study investigates the precise translational dynamics of lipid-coated microbubbles under ultrasound, revealing how their movement and stability can be optimized for targeted delivery in medical applications.

Contribution

The paper provides the first detailed experimental and theoretical analysis of microbubble translational motion considering history drag forces and bubble expansion effects.

Findings

Transport distance scales linearly with bubble expansion

Excellent agreement between experiments and theory when including history drag

Bubble dissolution increases sharply after a certain expansion threshold

Abstract

Ultrasound-driven microbubbles are increasingly being investigated for both molecular imaging and therapeutic applications. To be effective, these bubbles must be brought into close proximity or direct contact with the target site. Leveraging the acoustic radiation force provides a powerful strategy to direct their movement. In this study, we examine the translational dynamics of a microbubble with unprecedented accuracy by simultaneously time-resolving both its radial and translational responses and by using optical tweezers to study the bubble in free space. Our experimental results show excellent agreement with theoretical predictions for the bubble sizes considered, provided the history drag force is included in the force balance. For the Reynolds numbers considered (up to Re = 2), the zero-Reynolds-number history force performs as well as its finite-Reynolds-number extension. Although non-spherical modes may arise at larger bubble expansions, they do not appear to significantly influence the bubble translational motion. A major finding is that the normalised transport distance of the bubble scales linearly with the normalised volumetric expansion during its oscillation, greatly simplifying the design and analysis of transport strategies. We also investigated bubble stability during transport and observed a marked increase in dissolution rate once a threshold in bubble expansion is exceeded. These insights can be leveraged to develop optimal transport strategies that balance both transport speed and bubble stability for targeted delivery applications.