A Quantum Platform for Multiomics Data

TL;DR

This paper introduces a hybrid quantum-classical machine learning platform designed to analyze complex multiomics biological data, aiming to improve understanding of disease mechanisms and biological dynamics.

Contribution

It presents a novel encode-search-build approach for quantum-enhanced biological data analysis, addressing scalability and integration challenges in quantum computing for biology.

Findings

Proposes a hybrid platform for multiomics data analysis.

Demonstrates potential for quantum-enhanced classification and prediction.

Provides a scalable framework for future quantum biological research.

Abstract

The complexity of biological systems, governed by molecular interactions across hierarchical scales, presents a challenge for computational modeling. While advances in multiomic profiling have enabled precise measurements of biological components, classical computational approaches remain limited in capturing emergent dynamics critical for understanding disease mechanisms and therapeutic interventions. Quantum computing offers a new paradigm for addressing classically intractable problems, yet its integration into biological research remains nascent due to scalability barriers and accessibility gaps. Here, we introduce a hybrid quantum-classical machine learning platform designed to bridge this gap, with an encode-search-build approach which allows for efficiently extracting the most relevant information from biological data to \underline{encode} into a quantum state, provably efficient training algorithms to \underline{search} for optimal parameters, and a stacking strategy that allows one to systematically \underline{build} more complex models as more quantum resources become available. We propose to demonstrate the platform's utility through two initial use cases: quantum-enhanced classification of phenotypic states from molecular variables and prediction of temporal evolution in biological systems.