First Positronium Lifetime Imaging with Scandium-44 on a Long Axial Field-of-view PET/CT

TL;DR

This study demonstrates the first positronium lifetime imaging using Scandium-44 on a long axial FOV PET/CT, highlighting the potential and challenges of in vivo o-Ps measurements with this isotope.

Contribution

It introduces the first in vivo positronium lifetime imaging with 44Sc on a long-axial FOV PET/CT, analyzing count statistics and measurement uncertainties.

Findings

Measured o-Ps lifetimes are consistent with literature values for water.

Count statistics for three-photon events are limited by high prompt-photon energy.

Significant random coincidences increase statistical uncertainties in o-Ps lifetime measurements.

Abstract

Purpose: 44Sc has been successfully produced, synthesized, labeled and first-in-human studies were conducted some years ago. The decay properties of 44Sc, together with being close to a clinical implementation, make it an ideal candidate for in vivo positronium lifetime measurements. In this study, we investigate the count statistics for ortho-positronium (oPs) measurements with 44Sc. Method: A NEMA image quality phantom was filled with 41.7 MBq of 44Sc dissolved in water and scanned on a commercial long-axial field-of-view PET/CT. Three-photon events were identified using a prototype feature of the scanner and dedicated software. The lifetime of oPs was determined in the phantom spheres and in 4x4x4 mm^3 voxels. Results: All measured oPs lifetimes are compatible, within the uncertainties, with the literature values for water. The oPs lifetime is 2.65+-0.50, 1.39+-0.20 and 1.76+-0.18 ns in the three smallest spheres of the phantom and 1.79+-0.57 ns for a single voxel in the central region of the largest sphere. The relative standard deviation in the background regions of the time difference distributions, i.e., for time differences smaller than -2.7 ns, is above 20% - even for voxels inside the phantom spheres. Conclusions: Despite the favorable physical properties of 44Sc, the count statistics of three-photon events remains a challenge. The high prompt-photon energy causes a significant amount of random three-photon coincidences with the given methodology and, therefore, increases the statistical uncertainties on the measured oPs lifetime.