Hele-Shaw limit of chemotaxis-Navier-Stokes flows
Qingyou He, Ling-Yun Shou, Leyun Wu

TL;DR
This paper establishes the global existence of solutions for a chemotaxis-Navier-Stokes system with nonlinear diffusion and rigorously derives its limit as the diffusion becomes infinitely stiff, leading to a Hele-Shaw free boundary problem.
Contribution
It proves global solutions for the chemotaxis-Navier-Stokes system with general initial data and justifies the Hele-Shaw limit as the diffusion parameter tends to infinity.
Findings
Existence of global weak solutions for the system.
Convergence to Hele-Shaw free boundary problem as diffusion becomes stiff.
Verification of the complementarity relation in the limit.
Abstract
This paper investigates the connection between the chemotaxis--Navier--Stokes system with porous medium type nonlinear diffusion and the Hele--Shaw problem in (). First, we prove the global-in-time existence of weak solutions for the Cauchy problem of the chemotaxis-Navier-Stokes system with the general initial data, uniformly in the diffusion range . Then, we rigorously justify the Hele--Shaw limit for this system as , showing the convergence to a free boundary problem of Hele--Shaw type, where the bacterium (cell) diffusion is governed by the stiff pressure law. Moreover, the complementarity relation characterizing the limiting bacterium (cell) pressure via a degenerate elliptic equation is verified by a novel application of the Hele--Shaw framework.
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Taxonomy
TopicsMathematical Biology Tumor Growth · MRI in cancer diagnosis
