Differences in Neurovascular Coupling in Patients with Major Depressive Disorder: Evidence from Simultaneous Resting-State EEG-fNIRS

TL;DR

This study investigates how neurovascular coupling differs in major depressive disorder patients at various stages using simultaneous EEG-fNIRS, revealing potential biomarkers and recovery-related changes.

Contribution

It provides novel insights into altered neurovascular coupling in MDD through multimodal neuroimaging during resting state, highlighting recovery-related dynamics.

Findings

Higher coherence and correlation in maintenance phase patients

Shorter rise time in healthy controls compared to acute phase patients

Gradual recovery of neurovascular coupling during remission

Abstract

Neurovascular coupling (NVC) refers to the process by which local neural activity, through energy consumption, induces changes in regional cerebral blood flow to meet the metabolic demands of neurons. Event-related studies have shown that the hemodynamic response typically lags behind neural activation by 4-6 seconds. However, little is known about how NVC is altered in patients with major depressive disorder (MDD) and throughout the recovery process. In this study, we employed simultaneous resting-state electroencephalography (rsEEG) and functional near-infrared spectroscopy (fNIRS) to monitor neural and hemodynamic signals. Twelve patients with MDD during the acute phase, ten patients in the maintenance or consolidation phase, and six healthy controls were involved. We calculated the differences in coherence and temporal delay between spontaneous peak electrophysiological activity and hemodynamic responses across groups during the resting state in the prefrontal cortex (PFC). We found that the neural activity and its subsequent correlation with hemodynamic responses were significantly higher in patients during the maintenance phase. The rise time from the lowest to the highest point of correlation was shorter in healthy individuals than in patients in the acute phase, and gradually recovered during remission. By leveraging wearable neuroimaging techniques, this study reveals alterations in neurovascular coupling in depression and offers novel multimodal insights into potential biomarkers for MDD and its recovery process.