Laser Guided Microbubble Lithography for Multilayer Biophotonic Heterostructures

TL;DR

This paper introduces microbubble lithography, a bottom-up method for creating multilayered heterostructures suitable for microelectronics and biosensing, offering a cost-effective alternative to traditional techniques.

Contribution

The study presents a novel microbubble lithography technique for in situ multilayer microstructure fabrication, enabling material integration for biosensing applications.

Findings

Successful patterning of biomarker and reporter proteins

Demonstration of multilayer structure construction

Potential for environmentally sustainable sensing

Abstract

The fabrication of multilayered heterostructures is essential for advancing microelectronic and biosensing technologies. Conventional top-down manufacturing techniques are often cost-prohibitive and unsuitable for biomedical applications. Here, we present a bottom-up fabrication method, termed microbubble lithography, which enables the in situ construction of multilayered microstructures through layer-by-layer self-assembly. This technique allows diverse materials to be integrated into coherent heterostructures. We demonstrate the platform's utility by successfully patterning a biomarker and a reporter protein, highlighting its potential for cost-effective and environmentally sustainable sensing applications.