Transforming Expert Knowledge into Scalable Ontology via Large Language Models
Ikkei Itoku, David Theil, Evelyn Eichelsdoerfer Uehara, Sreyoshi Bhaduri, Junnosuke Kuroda, Toshi Yumoto, Alex Gil, Natalie Perez, Rajesh Cherukuri, Naumaan Nayyar

TL;DR
This paper presents a novel framework that leverages large language models combined with expert input and iterative prompt tuning to automate and scale taxonomy alignment with high accuracy, surpassing human performance.
Contribution
It introduces an innovative approach integrating LLMs, expert calibration, and prompt optimization for scalable, accurate taxonomy alignment in domain-specific applications.
Findings
Achieved an F1-score of 0.97 on a concept essentiality mapping task.
Outperformed the human benchmark of 0.68 in taxonomy alignment accuracy.
Demonstrated effective scaling of taxonomy alignment with high-quality results.
Abstract
Having a unified, coherent taxonomy is essential for effective knowledge representation in domain-specific applications as diverse terminologies need to be mapped to underlying concepts. Traditional manual approaches to taxonomy alignment rely on expert review of concept pairs, but this becomes prohibitively expensive and time-consuming at scale, while subjective interpretations often lead to expert disagreements. Existing automated methods for taxonomy alignment have shown promise but face limitations in handling nuanced semantic relationships and maintaining consistency across different domains. These approaches often struggle with context-dependent concept mappings and lack transparent reasoning processes. We propose a novel framework that combines large language models (LLMs) with expert calibration and iterative prompt optimization to automate taxonomy alignment. Our method…
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Taxonomy
TopicsBiomedical Text Mining and Ontologies · Topic Modeling · Semantic Web and Ontologies
