An AI-powered Knowledge Hub for Potato Functional Genomics

TL;DR

This paper introduces the Potato Knowledge Hub, an AI-powered platform that consolidates potato genomics research, resolves data inconsistencies, and provides an interactive AI assistant to facilitate research and breeding efforts.

Contribution

The study presents a novel integrated platform combining curated gene data, a knowledge base, and an AI assistant for potato genomics, addressing data inconsistency and accessibility issues.

Findings

Curated over 3,200 research papers spanning 120 years.

Mapped 2,571 genes to the latest reference genome with resolved nomenclature.

Developed an AI-powered research assistant for querying potato genomics data.

Abstract

Potato functional genomics lags due to unsystematic gene information curation, gene identifier inconsistencies across reference genome versions, and the increasing volume of research publications. To address these limitations, we developed the Potato Knowledge Hub (http://www.potato-ai.top), leveraging Large Language Models (LLMs) and a systematically curated collection of over 3,200 high-quality potato research papers spanning over 120 years. This platform integrates two key modules: a functional gene database containing 2,571 literature-reported genes, meticulously mapped to the latest DMv8.1 reference genome with resolved nomenclature discrepancies and links to original publications; and a potato knowledge base. The knowledge base, built using a Retrieval-Augmented Generation (RAG) architecture, accurately answers research queries with literature citations, mitigating LLM "hallucination." Users can interact with the hub via a natural language AI agent, "Potato Research Assistant," for querying specialized knowledge, retrieving gene information, and extracting sequences. The continuously updated Potato Knowledge Hub aims to be a comprehensive resource, fostering advancements in potato functional genomics and supporting breeding programs.