Robust and Annotation-Free Wound Segmentation on Noisy Real-World Pressure Ulcer Images: Towards Automated DESIGN-R\textsuperscript{\textregistered} Assessment

TL;DR

This paper introduces a robust, annotation-efficient wound segmentation pipeline that generalizes across different body sites using minimal supervision, enabling scalable and automated DESIGN-R assessment without extensive retraining.

Contribution

The authors present a zero fine-tuning, annotation-light wound segmentation method combining YOLOv11n and FUSegNet, capable of generalizing across diverse wound types without pixel-level annotations.

Findings

Improved mean IoU by 23 percentage points over baseline.

Increased DESIGN-R size estimation accuracy from 71% to 94%.

Effective cross-site wound segmentation with minimal supervision.

Abstract

Purpose: Accurate wound segmentation is essential for automated DESIGN-R scoring. However, existing models such as FUSegNet, which are trained primarily on foot ulcer datasets, often fail to generalize to wounds on other body sites. Methods: We propose an annotation-efficient pipeline that combines a lightweight YOLOv11n-based detector with the pre-trained FUSegNet segmentation model. Instead of relying on pixel-level annotations or retraining for new anatomical regions, our method achieves robust performance using only 500 manually labeled bounding boxes. This zero fine-tuning approach effectively bridges the domain gap and enables direct deployment across diverse wound types. This is an advance not previously demonstrated in the wound segmentation literature. Results: Evaluated on three real-world test sets spanning foot, sacral, and trochanter wounds, our YOLO plus FUSegNet pipeline improved mean IoU by 23 percentage points over vanilla FUSegNet and increased end-to-end DESIGN-R size estimation accuracy from 71 percent to 94 percent (see Table 3 for details). Conclusion: Our pipeline generalizes effectively across body sites without task-specific fine-tuning, demonstrating that minimal supervision, with 500 annotated ROIs, is sufficient for scalable, annotation-light wound segmentation. This capability paves the way for real-world DESIGN-R automation, reducing reliance on pixel-wise labeling, streamlining documentation workflows, and supporting objective and consistent wound scoring in clinical practice. We will publicly release the trained detector weights and configuration to promote reproducibility and facilitate downstream deployment.