Expectation-maximization for low-SNR multi-reference alignment
Amnon Balanov, Wasim Huleihel, and Tamir Bendory

TL;DR
This paper analyzes the expectation-maximization algorithm for multi-reference alignment at low signal-to-noise ratios, revealing fundamental convergence bottlenecks, sensitivity to initialization, and the impact of Fourier phase preservation on reconstruction quality.
Contribution
It provides a detailed characterization of EM's convergence dynamics, initialization dependence, and introduces the 'Ghost of Newton' instability in low-SNR MRA.
Findings
EM exhibits a two-phase convergence with exponential decay rates depending on SNR.
Iteration complexity to reach accurate reconstruction scales as SNR^{-2}.
Fourier phases are preserved during EM iterations, while magnitudes contract slowly.
Abstract
We study the multi-reference alignment (MRA) problem of recovering a signal from noisy observations acted on by unknown random circular shifts. While the information-theoretic limits of MRA are well characterized in many settings, the algorithmic behavior at low signal-to-noise ratio (SNR), the regime of practical interest, remains poorly understood. In this paper, we analyze the expectation-maximization (EM) algorithm, a widely used method for MRA, and characterize its convergence dynamics and initialization dependence in the low-SNR limit. On the convergence side, we prove a two-phase phenomenon near the ground truth as : an initial contraction with error decaying as followed by a much slower phase scaling as , where is the iteration number. This yields an iteration-complexity lower bound $T…
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Taxonomy
TopicsGenomics and Phylogenetic Studies · Gene expression and cancer classification · Machine Learning in Bioinformatics
