Radionuclide Production for Dose Verification in VHEE FLASH Radiotherapy
Francesco Urso, Federica Baffigi, Esther Ciarrocchi, Leonida Antonio Gizzi, Petra Koester, Luca Labate, Matteo Morrocchi, Simona Piccinini, Martina Salvadori, Maria Giuseppina Bisogni
TL;DR
This paper investigates radionuclide production in PMMA phantoms irradiated with VHEE beams using simulations and experiments, aiming to develop a novel dose verification method for FLASH radiotherapy.
Contribution
It introduces a combined Monte Carlo simulation and experimental approach to study radionuclide production for dose verification in VHEE FLASH radiotherapy.
Findings
Radionuclides 11C, 15O, and 13N are produced via photonuclear reactions.
Spatial distribution and yields of radionuclides are characterized.
Decay times of radionuclides are analyzed for dose verification potential.
Abstract
This study explores the production of radionuclides in a PMMA (Polymethylmethacrylate) phantom irradiated with Very High Energy Electrons (VHEE) beams as a novel method for dose verification. In this work, Monte Carlo simulation studies using the Geant4 toolkit and experimental measurements with a VHEE beam produced by a laser-plasma accelerator were conducted. Specifically, the photonuclear production of 11C, 15O and 13N is examined, with a detailed analysis of their spatial distribution, production yields and decay time
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Taxonomy
TopicsAdvanced Radiotherapy Techniques · Radiation Therapy and Dosimetry · Nuclear Physics and Applications