M-learner:A Flexible And Powerful Framework To Study Heterogeneous Treatment Effect In Mediation Model
Xingyu Li, Qing Liu, Tony Jiang, Hong Amy Xia, Brian P. Hobbs, Peng Wei

TL;DR
The paper introduces the M-learner, a novel framework for estimating and identifying heterogeneity in indirect and total treatment effects within mediation models, combining effect estimation with clustering techniques.
Contribution
It presents the first method specifically designed to capture treatment effect heterogeneity in mediation models, integrating effect estimation with clustering for subgroup identification.
Findings
Robustness and effectiveness demonstrated through experiments
Successfully applied to real-world Jobs II dataset
Broad applicability across different datasets and contexts
Abstract
We propose a novel method, termed the M-learner, for estimating heterogeneous indirect and total treatment effects and identifying relevant subgroups within a mediation framework. The procedure comprises four key steps. First, we compute individual-level conditional average indirect/total treatment effect Second, we construct a distance matrix based on pairwise differences. Third, we apply tSNE to project this matrix into a low-dimensional Euclidean space, followed by K-means clustering to identify subgroup structures. Finally, we calibrate and refine the clusters using a threshold-based procedure to determine the optimal configuration. To the best of our knowledge, this is the first approach specifically designed to capture treatment effect heterogeneity in the presence of mediation. Experimental results validate the robustness and effectiveness of the proposed framework. Application…
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Taxonomy
Methodsk-Means Clustering
