Engineered Zwitterion-Infused Clay Composites with Antibacterial and Antifungal Efficacy

TL;DR

This paper presents a novel, sustainable clay-based bandage with embedded zwitterions, silver ions, and terbinafine hydrochloride, demonstrating effective antibacterial and antifungal properties for wound healing.

Contribution

It introduces an innovative organo-functionalized clay composite with embedded antimicrobial agents, offering a scalable and cost-effective solution for infection-resistant wound dressings.

Findings

Demonstrated antimicrobial efficacy against S. aureus, E. coli, and C. albicans.

Developed a hybrid membrane with sustained release of antimicrobial agents.

Showed potential for point-of-care wound healing applications.

Abstract

Microbes and pathogens play a detrimental role in healing wounds, causing infections like impetigo through bodily fluids and skin and entering the bloodstream through the wounds, thereby hindering the healing process and tissue regeneration. Clay, known for its long history of natural therapeutic use, has emerged as one of the most promising candidates for biomedical applications due to its non-toxic nature, porosity, high surface area, ubiquity, and excellent cation exchange capacity. This study demonstrates an innovative approach to engineering an organo-functionalized, infection-resistant, easy-to-use bandage material from clay, an environmentally benign and sustainable material. The hybrid membranes have been developed using clays, zwitterions, silver ions, and terbinafine hydrochloride (TBH) to impart antibacterial and antifungal efficacy. A critical aspect of this study is embedding organic molecules and metal ions with the clays and releasing them to resist the growth and kill the pathogens. The antimicrobial efficacy of the membranes has been tested using a zone of inhibition study against the most common microbes in skin wounds, viz. S. aureus, E. coli, and C. albicans. Results from our studies not only demonstrate the potential of these hybrid clay membranes as a cost-effective, scalable, and effective solution for treating microbial infections but also instill newer avenues for point-of-care wound-healing treatments, offering hope for improved patient outcomes.