Multi-Omics Fusion with Soft Labeling for Enhanced Prediction of Distant Metastasis in Nasopharyngeal Carcinoma Patients after Radiotherapy

TL;DR

This paper introduces a novel multi-omics fusion method with soft labeling to improve the prediction of distant metastasis in nasopharyngeal carcinoma patients post-radiotherapy, addressing data disparity challenges.

Contribution

It develops a flexible multi-kernel late-fusion approach with soft labels to enhance prediction accuracy in complex NPC datasets.

Findings

Model shows robustness on NPC-ContraParotid dataset

Improves prediction of distant metastasis in NPC patients

Addresses data disparity in multi-omics integration

Abstract

Omics fusion has emerged as a crucial preprocessing approach in the field of medical image processing, providing significant assistance to several studies. One of the challenges encountered in the integration of omics data is the presence of unpredictability arising from disparities in data sources and medical imaging equipment. In order to overcome this challenge and facilitate the integration of their joint application to specific medical objectives, this study aims to develop a fusion methodology that mitigates the disparities inherent in omics data. The utilization of the multi-kernel late-fusion method has gained significant popularity as an effective strategy for addressing this particular challenge. An efficient representation of the data may be achieved by utilizing a suitable single-kernel function to map the inherent features and afterward merging them in a space with a high number of dimensions. This approach effectively addresses the differences noted before. The inflexibility of label fitting poses a constraint on the use of multi-kernel late-fusion methods in complex nasopharyngeal carcinoma (NPC) datasets, hence affecting the efficacy of general classifiers in dealing with high-dimensional characteristics. This innovative methodology aims to increase the disparity between the two cohorts, hence providing a more flexible structure for the allocation of labels. The examination of the NPC-ContraParotid dataset demonstrates the model's robustness and efficacy, indicating its potential as a valuable tool for predicting distant metastases in patients with nasopharyngeal carcinoma (NPC).