On a Brain Tumor Growth Model with Lactate Metabolism, Viscoelastic Effects, and Tissue Damage

TL;DR

This paper develops and analyzes a complex mathematical model of brain tumor growth that incorporates lactate metabolism, tissue viscoelasticity, and reversible tissue damage, providing rigorous proof of solution existence and regularity.

Contribution

It introduces a novel coupled PDE system for tumor growth with lactate, viscoelastic effects, and tissue damage, and proves well-posedness and regularity of solutions.

Findings

Existence of global weak solutions established.

Solutions depend continuously on initial data.

Regularity properties of solutions demonstrated.

Abstract

In this paper, we study a nonlinearly coupled initial-boundary value problem describing the evolution of brain tumor growth including lactate metabolism. In our modeling approach, we also take into account the viscoelastic properties of the tissues as well as the reversible damage effects that could occur, possibly caused by surgery. After introducing the PDE system, coupling a Fischer-Kolmogorov type equation for the tumor phase with a reaction-diffusion equation for the lactate, a quasi-static momentum balance with nonlinear elasticity and viscosity matrices, and a nonlinear differential inclusion for the damage, we prove the existence of global in time weak solutions under reasonable assumptions on the involved functions and data. Strengthening these assumptions, we subsequently prove further regularity properties of the solutions as well as their continuous dependence with respect to the data, entailing the well-posedness of the Cauchy problem associated with the nonlinear PDE system.