TROI: Cross-Subject Pretraining with Sparse Voxel Selection for Enhanced fMRI Visual Decoding

TL;DR

This paper introduces TROI, a data-driven, two-stage ROI labeling method for cross-subject fMRI visual decoding, improving voxel selection and decoding accuracy especially with limited data.

Contribution

TROI provides an automated, efficient voxel selection and input layer optimization approach for cross-subject fMRI decoding, reducing reliance on manual ROI labeling.

Findings

Outperforms MindEye2 in voxel selection accuracy

Enhances brain visual retrieval and reconstruction performance

Effective with limited subject samples

Abstract

fMRI (functional Magnetic Resonance Imaging) visual decoding involves decoding the original image from brain signals elicited by visual stimuli. This often relies on manually labeled ROIs (Regions of Interest) to select brain voxels. However, these ROIs can contain redundant information and noise, reducing decoding performance. Additionally, the lack of automated ROI labeling methods hinders the practical application of fMRI visual decoding technology, especially for new subjects. This work presents TROI (Trainable Region of Interest), a novel two-stage, data-driven ROI labeling method for cross-subject fMRI decoding tasks, particularly when subject samples are limited. TROI leverages labeled ROIs in the dataset to pretrain an image decoding backbone on a cross-subject dataset, enabling efficient optimization of the input layer for new subjects without retraining the entire model from scratch. In the first stage, we introduce a voxel selection method that combines sparse mask training and low-pass filtering to quickly generate the voxel mask and determine input layer dimensions. In the second stage, we apply a learning rate rewinding strategy to fine-tune the input layer for downstream tasks. Experimental results on the same small sample dataset as the baseline method for brain visual retrieval and reconstruction tasks show that our voxel selection method surpasses the state-of-the-art method MindEye2 with an annotated ROI mask.