Effect of a new type of healthy and live food supplement on osteoporosis blood parameters and induced rheumatoid arthritis in Wistar rats

TL;DR

This study evaluates a new organic food supplement, NBS, demonstrating its potential to restore blood parameters and reduce inflammation in rat models of osteoporosis and rheumatoid arthritis.

Contribution

The paper introduces a novel green-synthesized food supplement, NBS, with therapeutic effects on osteoporosis and rheumatoid arthritis in rats, showing dose-dependent efficacy.

Findings

50 mg/kg dose had the highest therapeutic effect

NBS normalized blood osteoporotic and rheumatoid factors

The supplement reduced joint inflammation in rats

Abstract

Summary Osteoporosis is a skeletal disorder, characterized by a decrease in bone strength and puts the individual at risk for fracture. On the other hand, rheumatoid arthritis is a systemic disease of unknown etiology that causes inflammation of the joints of the organs. Purpose Due to the destructive effects of these diseases and its increasing prevalence and lack of appropriate medication for treatment, the present study aimed to evaluate the therapeutic effect of a new type of healthy and live food supplement on rheumatoid arthritis and induced osteoporosis in rats. Methods In this research, healthy and live food powder were synthesized by a new and green route. This organic biomaterial was named NBS. The NBS food supplement had various vitamins, macro and micro molecules, and ingredients. The new healthy and nutritious diet showed that the use of this supplement led to the return of the parameters to normal levels. Results The concentration of 12.5 mg/ kg showed the least therapeutic effect and 50 mg/ kg had the highest therapeutic effect for osteoporosis. The results of blood parameters involved in inflammation in both healthy and patient groups showed that the use of complete adjuvant induction causes joint inflammation. In the study of the interaction of the concentrations, it was observed that the concentration of 50 mg/ kg had the highest therapeutic effect against the disease in the studied mice. Conclusion The results showed that the new healthy and viable supplement restores the blood osteoporotic and rheumatoid factors of the mice to normal.