Segmentation-Aware Generative Reinforcement Network (GRN) for Tissue Layer Segmentation in 3-D Ultrasound Images for Chronic Low-back Pain (cLBP) Assessment

TL;DR

This paper presents a novel segmentation-aware generative reinforcement network (GRN) framework for efficient 3D ultrasound tissue segmentation, significantly reducing labeling efforts while maintaining high accuracy for chronic low-back pain assessment.

Contribution

The paper introduces a joint training framework called GRN that integrates segmentation feedback and a segmentation-guided enhancement technique, with variants for semi-supervised and sample-efficient learning.

Findings

GRN-SEL with SGE reduces labeling by 70% and improves DSC by 1.98%.

GRN-SSL with SGE decreases labeling needs by 70%, maintaining performance.

The framework achieves high segmentation accuracy with significantly less labeled data.

Abstract

We introduce a novel segmentation-aware joint training framework called generative reinforcement network (GRN) that integrates segmentation loss feedback to optimize both image generation and segmentation performance in a single stage. An image enhancement technique called segmentation-guided enhancement (SGE) is also developed, where the generator produces images tailored specifically for the segmentation model. Two variants of GRN were also developed, including GRN for sample-efficient learning (GRN-SEL) and GRN for semi-supervised learning (GRN-SSL). GRN's performance was evaluated using a dataset of 69 fully annotated 3D ultrasound scans from 29 subjects. The annotations included six anatomical structures: dermis, superficial fat, superficial fascial membrane (SFM), deep fat, deep fascial membrane (DFM), and muscle. Our results show that GRN-SEL with SGE reduces labeling efforts by up to 70% while achieving a 1.98% improvement in the Dice Similarity Coefficient (DSC) compared to models trained on fully labeled datasets. GRN-SEL alone reduces labeling efforts by 60%, GRN-SSL with SGE decreases labeling requirements by 70%, and GRN-SSL alone by 60%, all while maintaining performance comparable to fully supervised models. These findings suggest the effectiveness of the GRN framework in optimizing segmentation performance with significantly less labeled data, offering a scalable and efficient solution for ultrasound image analysis and reducing the burdens associated with data annotation.