Theoretical Models for Tension-Dependent DNA Looping Time

TL;DR

This paper introduces a new theoretical model for DNA looping under tension, showing superior agreement with simulations and clarifying differences with previous models, thus advancing understanding of DNA mechanics.

Contribution

A novel theoretical model for tension-dependent DNA looping that aligns closely with simulations and clarifies its relation to existing models.

Findings

New model demonstrates exceptional agreement with simulations for long semiflexible chains.

Clarifies the relationship between the new model and the two-state model.

Provides predictive insights for future experimental validation.

Abstract

The influence of tension on DNA looping has been studied both experimentally and theoretically in the past. However, different theoretical models have yielded different predictions, leaving uncertainty about their validity. We briefly review the predictions of those models and propose a novel model that demonstrates exceptional agreement with simulations for long semiflexible chains. Additionally, we elucidate the relationship between our result and that of the previously proposed two-state model, highlighting the distinct interpretative approach that underpins our framework. Our findings offer predictive insights that pave the way for future experimental validation.