CHEmical-shift selective Adiabatic Pulse (CHEAP): Fast and High Resolution Downfield 3D 1H-MRSI at 7T

TL;DR

This paper introduces CHEAP-EPSI, a novel 3D-MRSI technique at 7T that enhances spatial resolution and reduces scan time for detecting downfield brain metabolites, aiding research and diagnosis.

Contribution

The study develops and demonstrates CHEAP-EPSI, a new method integrating CHEAP pulses with EPSI for fast, high-resolution downfield 1H-MRSI at 7T, overcoming previous limitations.

Findings

Achieved spatial resolution of 0.37 ml

Reduced scan time to 10.5 minutes

Enhanced detection of downfield metabolites

Abstract

The key molecules such as triphosphate (ATP), glutathione (GSH), and homocarnosine (hCs) - central to metabolic processes in the human brain remain elusive or challenging to detect with upfield 1H-MRSI. Traditional 3D 1H-MRSI in vivo faces challenges, including a low signal-to-noise ratio and magnetization transfer effects with water, leading to prolonged measurement times and reduced resolution. To address these limitations, we propose a downfield 3D-MRSI method aimed at measuring downfield metabolites with enhanced spatial resolution, and speed acceptable for clinical practice at 7T. The CHEmical-shift selective Adiabatic Pulse (CHEAP) technique was integrated into echo-planar spectroscopic imaging (EPSI) readout sequence for downfield metabolite and water reference 3D-MRSI. Five healthy subjects and two glioma patients were scanned to test the feasibility. In this work, CHEAP-EPSI technique is shown to significantly enhance spatial the resolution to 0.37 ml while simultaneously reducing the scan time to 10.5 minutes. Its distinct advantages include low specific absorption rate, effective suppression of water and lipid signals, and minimal baseline distortions, making it a valuable tool for research or potentially diagnostic purposes. CHEAP-EPSI improves the detection sensitivity of downfield metabolites like N-acetyl-aspartate (NAA+) and DF8.18 (ATP&GSH+), and offers new possibilities for the study of metabolism in healthy and diseased brain.