Tailoring the Glucose Oxidation Activity of Anodized Copper Films on Microfabricated Platforms

TL;DR

This paper investigates how anodization parameters influence glucose oxidation on copper films, demonstrating improved sensitivity and detection limits for biosensing applications through scalable manufacturing techniques.

Contribution

It provides new insights into controlling copper oxide species via anodization to enhance catalytic activity for glucose sensing.

Findings

Sensitivity increased by up to 73% with anodization.

Detection limit as low as 0.004 mM achieved.

Scalable, reproducible fabrication on microfabricated platforms.

Abstract

Glucose oxidation is a key reaction in biosensing and energy conversion, with anodized copper electrodes showing great potential as catalysts for its enhancement. This study explores the relationship between anodization parameters and glucose oxidation on thin copper films, providing valuable insights for optimization. By adjusting anodization parameters, specific species such as Cu2O, Cu(OH)2, and CuO can be selectively formed, each exhibiting different catalytic activities. Applying polarization in 1 M KOH at 0 V (vs Ag|AgCl) generates a highly active CuO surface layer, leading to significant performance improvements over bare copper electrodes. Specifically, sensitivity increases by 55% in the 0.1 mM-0.5 mM range and 73% in the 0.75 mM-2 mM range. Additionally, the electrodes demonstrate an exceptionally low detection limit of just 0.004 mM. These results are attributed to scalable, reproducible manufacturing on cleanroom-compatible platforms. This study not only sheds light on the effects of thin copper film anodization on glucose oxidation but also provides a practical approach for enhancing the efficiency of copper-based systems in biosensing and energy conversion applications.