Viral Lattice Theory: A Biophysical Model for Virion Motion

TL;DR

This paper introduces a novel biophysical framework modeling virion motion as a lattice of coupled vibrational modes, combining physics and wave mechanics to analyze infectivity and suggest antiviral strategies.

Contribution

It develops an operator-based model merging condensed matter physics and quantum-inspired theory to analyze virion collective behavior and vibrational dynamics.

Findings

Virion motion can be modeled as lattice vibrations similar to phonons.

Short-lived lattice states may sustain infectivity in aerosols.

Fundamental limits on capsid rigidity and vibrational response are identified.

Abstract

We present a rigorously formulated, novel operator-based framework that merges ideas from condensed matter physics, continuum mechanics, and quantum-inspired theory to analyze collective virion behavior in complex environments. By modeling metabolically inert virions, whose main interactions are Coulombic and Lennard-Jones, as nodes in a viral lattice linked by effective springs, we obtain collective vibrational modes akin to phonons in solids. A coupled, complex-valued displacement field PDE underpins our approach, enabling wave mechanics and functional analysis to define key observables, ranging from stress fields and thermodynamic responses to effective Hamiltonians. We interpret the apparent stochasticity of virion motion as deterministic chaos arising from rapid transitions among 'viral phonon' modes that store and redistribute energy from the host. Short-lived lattice states (picoseconds) may thus help sustain infectivity in aerosolized droplets of respiratory virions. Extending our operator framework, we derive an uncertainty-like relation coupling a virion's self-stiffness operator with its phononic frequency operator, underscoring fundamental limits on specifying capsid rigidity and vibrational response. We also explore transient coherence effects, akin to entanglement witness operators, which may expose critical correlations affecting capsid resilience or genome release. Our approach invites experimental validation via advanced imaging, high-resolution spectroscopy, and mechanical perturbations. By integrating aspects of soft matter physics, crystallography, statistical mechanics, and wave-based modeling, this methodology suggests new antiviral strategies targeting specific vibrational modes and guides the rational design of virus-based vectors in therapeutic or diagnostic applications.