Genomic and pathological analyses of an asymmetric true hermaphroditism case in a female labrador retriever

TL;DR

This paper reports a novel case of asymmetric true hermaphroditism in a female Labrador retriever, combining genomic and pathological analyses to expand understanding of gonadal development disorders in dogs.

Contribution

It presents the first documented case of asymmetric true hermaphroditism in a Labrador retriever with detailed genomic and pathological insights.

Findings

First case of asymmetric true hermaphroditism in a Labrador retriever

Genomic analysis reveals XX sex reversal characteristics

Pathological analysis confirms presence of ovarian and testicular tissues

Abstract

The two main gonadal development disorders in dogs are true hermaphroditism and XX male syndrome. True hermaphroditism can be divided into two subcategories: XX sex reversal and XY sex reversal. XX Sry-negative sex reversal is more common, and it is characterized by the presence of both ovarian and testicular tissues in an animal. To date, there are 16 cases of true hermaphroditism reported in the literature, 15 of which are XX true hermaphroditism. Hermaphroditism has not been formally documented in labrador retrievers, and no case of asymmetric hermaphroditism has been reported in the literature.