Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial

TL;DR

Sundial is a novel molecular dynamics framework that models biological aging, providing unbiased age estimation and aging forecasts, revealing links between faster aging and increased disease risk.

Contribution

The paper introduces Sundial, a new diffusion-based model that captures both population and individual aging dynamics, addressing biases in existing aging clocks.

Findings

Faster aging individuals have higher disease risks.

Sundial accurately estimates biological age.

It enables forecasting of aging trajectories.

Abstract

Addressing the unavoidable bias inherent in supervised aging clocks, we introduce Sundial, a novel framework that models molecular dynamics through a diffusion field, capturing both the population-level aging process and the individual-level relative aging order. Sundial enables unbiasedestimation of biological age and the forecast of aging roadmap. Fasteraging individuals from Sundial exhibit a higher disease risk compared to those identified from supervised aging clocks. This framework opens new avenues for exploring key topics, including age- and sex-specific aging dynamics and faster yet healthy aging paths.