The impact of simultaneous infections on phage-host ecology

TL;DR

This paper develops a theoretical model to understand how simultaneous phage infections affect bacterial host dynamics, revealing conditions for coexistence, extinction, and implications for phage therapy.

Contribution

It introduces a novel theory of simultaneous phage infections, highlighting their ecological impact and potential applications in phage therapy.

Findings

Simultaneous infections can lead to bi-stability in phage-host systems.

Phages can persist even when their basic reproductive number is below one.

Periodic oscillations in phage and host populations can occur under certain conditions.

Abstract

Phages use bacterial host resources to replicate, intrinsically linking phage and host survival. To understand phage dynamics, it is essential to understand phage-host ecology. A key step in this ecology is infection of bacterial hosts. Previous work has explored single and multiple, sequential infections. Here we focus on the theory of simultaneous infections, where multiple phages simultaneously attach to and infect one bacterial host cell. Simultaneous infections are a relevant infection dynamic to consider, especially at high phage densities when many phages attach to a single host cell in a short time window. For high bacterial growth rates, simultaneous infection can result in bi-stability: depending on initial conditions phages go extinct or co-exist with hosts, either at stable densities or through periodic oscillations of a stable limit cycle. This bears important consequences for phage applications such as phage therapy: phages can persist even though they cannot invade. Consequently, through spikes in phage densities it is possible to infect a bacterial population even when the phage basic reproductive number is less than one. In the regime of stable limit cycles, if timed right, only small densities of phage may be necessary.