Old vaccines, new usages, surprisingly effective in solving the century-old problem -Inactivated African Swine Fever Virus vaccine induces safe and efficient immune protection through mucosal immunity

TL;DR

This study demonstrates that an inactivated African Swine Fever Virus vaccine, created with propiolactone, is both safe and highly effective in inducing mucosal immunity and protecting pigs from ASF, addressing a century-old challenge.

Contribution

The paper introduces a novel inactivated ASF vaccine using propiolactone that provides high protection and safety, a significant advancement over previous vaccine attempts.

Findings

98.6% protection within 100 days

Effective mucosal immune response

Safe and efficient vaccine candidate

Abstract

Background: African swine fever is among the most devastating viral diseases of pigs. Despite nearly a century of research, there is still no safe and effective vaccine available. The current situation is that either vaccines are safe but not effective, or they are effective but not safe.Findings: The ASF vaccine prepared using the inactivation method with propiolactone provided 98.6% protection within 100 days after three intranasal immunizations, spaced 7 days apart.Conclusions: An inactivated vaccine made from complete African swine fever virus particles using propiolactone is safe and effective for controlling ASF through mucosal immunity.