MHSA: A Multi-scale Hypergraph Network for Mild Cognitive Impairment Detection via Synchronous and Attentive Fusion

TL;DR

This paper introduces MHSA, a novel multi-scale hypergraph network that models synchronized brain region interactions using phase-locking values and spectrum-temporal fusion to improve mild cognitive impairment detection.

Contribution

It proposes a new hypergraph modeling framework that captures synchronized brain activity across multiple scales using spectrum and temporal domain fusion.

Findings

Effective in real-world MCI detection datasets

Improves modeling of brain region synchronization

Demonstrates superior performance over existing methods

Abstract

The precise detection of mild cognitive impairment (MCI) is of significant importance in preventing the deterioration of patients in a timely manner. Although hypergraphs have enhanced performance by learning and analyzing brain networks, they often only depend on vector distances between features at a single scale to infer interactions. In this paper, we deal with a more arduous challenge, hypergraph modelling with synchronization between brain regions, and design a novel framework, i.e., A Multi-scale Hypergraph Network for MCI Detection via Synchronous and Attentive Fusion (MHSA), to tackle this challenge. Specifically, our approach employs the Phase-Locking Value (PLV) to calculate the phase synchronization relationship in the spectrum domain of regions of interest (ROIs) and designs a multi-scale feature fusion mechanism to integrate dynamic connectivity features of functional magnetic resonance imaging (fMRI) from both the temporal and spectrum domains. To evaluate and optimize the direct contribution of each ROI to phase synchronization in the temporal domain, we structure the PLV coefficients dynamically adjust strategy, and the dynamic hypergraph is modelled based on a comprehensive temporal-spectrum fusion matrix. Experiments on the real-world dataset indicate the effectiveness of our strategy. The code is available at https://github.com/Jia-Weiming/MHSA.