Detecting Daily Living Gait Amid Huntington's Disease Chorea using a Foundation Deep Learning Model

TL;DR

This paper introduces J-Net, a deep learning model that accurately detects gait in daily living for individuals with Huntington's disease and other neurodegenerative disorders, outperforming existing methods.

Contribution

We developed J-Net, a novel foundation deep learning model fine-tuned for gait detection in neurodegenerative diseases, improving accuracy and clinical relevance over prior approaches.

Findings

J-Net achieved 0.97 ROC-AUC in in-lab gait detection for HD.

J-Net's gait estimates showed no significant difference between HD and controls in daily living.

Gait detection by J-Net correlated with clinical severity scores.

Abstract

Wearable sensors offer a non-invasive way to collect physical activity (PA) data, with walking as a key component. Existing models often struggle to detect gait bouts in individuals with neurodegenerative diseases (NDDs) involving involuntary movements. We developed J-Net, a deep learning model inspired by U-Net, which uses a pre-trained self-supervised foundation model fine-tuned with Huntington`s disease (HD) in-lab data and paired with a segmentation head for gait detection. J-Net processes wrist-worn accelerometer data to detect gait during daily living. We evaluated J-Net on in-lab and daily-living data from HD, Parkinson`s disease (PD), and controls. J-Net achieved a 10-percentage point improvement in ROC-AUC for HD over existing methods, reaching 0.97 for in-lab data. In daily-living environments, J-Net estimates showed no significant differences in median daily walking time between HD and controls (p = 0.23), in contrast to other models, which indicated counterintuitive results (p < 0.005). Walking time measured by J-Net correlated with the UHDRS-TMS clinical severity score (r=-0.52; p=0.02), confirming its clinical relevance. Fine-tuning J-Net on PD data also improved gait detection over current methods. J-Net`s architecture effectively addresses the challenges of gait detection in severe chorea and offers robust performance in daily living. The dataset and J-Net model are publicly available, providing a resource for further research into NDD-related gait impairments.