Using data collected from structured light plethysmography to differentiate breathing pattern disorder from normal breathing: A study group report

TL;DR

This study investigates the potential of structured light plethysmography (SLP) data to distinguish breathing pattern disorder from normal breathing in post-COVID patients, exploring various analytical approaches without definitive biomarkers.

Contribution

It evaluates multiple data analysis methods on SLP data from healthy and BPD patients, providing insights and recommendations for future research.

Findings

No clear SLP biomarkers identified for BPD

Explored dimensionality reduction and index extraction techniques

Proposed future directions including spatial indices and mechanical modeling

Abstract

This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by SofTMech and Innovate UK, Business Connect. This report summarises the work undertaken on a challenge presented by two of the authors, Mathew Bulpett and Dr Emily Fraser. The aim was to identify approaches to analyse data collected using structured light plethysmography (SLP) from (n=31) healthy volunteers and (n=67) patients with Breathing Pattern Disorder (BPD) attributed to "long COVID", i.e. post-acute COVID-19 sequelae. This report explores several approaches including dimensionality reduction techniques on the available data and alternative indices extracted from variation in the time-series data for each measurement. Further proposals are also outlined such as different spatial indices that could be extracted from the SLP data, and the potential to couple to mechanical models of the lungs, chest and abdomen. However, running these latter analyses was beyond the scope of the limited study group timeframe. This exploratory analysis did not identify any clear SLP biomarkers of BPD in these cohorts, however recommendations are made for using SLP technologies in future BPD studies based on its findings.