Task learning through stimulation-induced plasticity in neural networks

TL;DR

This paper demonstrates a method to steer neural networks towards desired functions using stimulation-induced plasticity, enabling in vitro computation with real neurons.

Contribution

It introduces a control procedure leveraging synaptic plasticity to guide neural networks to specific functional states, a novel approach in bioengineering.

Findings

Successfully drives networks to desired states via stimulation

Demonstrates non-linear association task performance

Constructs continuous attractors in neural populations

Abstract

Synaptic plasticity dynamically shapes the connectivity of neural systems and is key to learning processes in the brain. To what extent the mechanisms of plasticity can be exploited to drive a neural network and make it perform some kind of computational task remains unclear. This question, relevant in a bioengineering context, can be formulated as a control problem on a high-dimensional system with strongly constrained and non-linear dynamics. We present a self-contained procedure which, through appropriate spatio-temporal stimulations of the neurons, is able to drive rate-based neural networks with arbitrary initial connectivity towards a desired functional state. We illustrate our approach on two different computational tasks: a non-linear association between multiple input stimulations and activity patterns (representing digit images), and the construction of a continuous attractor encoding a collective variable in a neural population. Our work thus provides a proof of principle for emerging paradigms of in vitro computation based on real neurons.